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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
TKL BRAF 456
CAMK CAMK2B 14
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
TK EGFR 712
TK FGFR1 478
TK JAK2 849
TK JAK3 822
CMGC MAPK14 24
AGC PRKCD 349
AGC PRKCQ 380
TK PTK2 422
TK RET 724
STE SLK 34
CAMK STK17B 33
--F-NFIKVLGKGSFGKVMLAELK-------GKDEVYAVKVLKKD-V-ILQDD--DVDCTMTEKRILALA-RKHPYLTQLYCCFQ--T------KDRLFFVMEYVNGGDLMFQIQ---RSR-------------------------KFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHC---KLADFGMCKEG----ILNGVTTTT---FCGTPDYIAPEILQ-----ELE---YGPSVDWWALGVLMYEMMA-GQPP---------------FEAD----NEDDLFESILH----DDVLYPVWLS----------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPS-------FA-EIHQA--F--
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPM-------LR-EVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKS-Q-IEKEG--VEHQLRREIEIQAHL--HHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ---KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL---KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-----GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVK----VDLKFPASVP----------------------------MGAQDLISKLLRHNPSERLP-------LA-QVSAHPWV--
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH----II-----------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTV---KIGDFGLATVK--S-R--WSGSHQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPL-------FP-QILA---SI-
---YQLYEDIGKGAFSVVRRCVKL-------CTGHEYAAKIINTK-K-LSARD--HQKLER-EARICRLL--KHSNIVRLHDSIS--E------EGFHYLVFDLVTGGELFEDIV---ARE-------------------------YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-----KEA---YGKPVDIWACGVILYILLV-GYPP---------------FWDE----DQHKLYQQIKA----GAYDFPSPEWDTVT------------------------PEAKNLINQMLTINPAKRIT-------AH-EALKHPWV--
---YQLFEELGKGAFSVVRRCMKI-------PTGQEYAAKIINTK-K-LSARD--HQKLER-EARICRLL--KHPNIVRLHDSIS--E------EGFHYLVFDLVTGGELFEDIV---ARE-------------------------YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-----KDP---YGKPVDMWACGVILYILLV-GYPP---------------FWDE----DQHRLYQQIKA----GAYDFPSPEWDTVT------------------------PEAKDLINKMLTINPAKRIT-------AS-EALKHPWI--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE-S-EEEGV--PSTAIR-EISLLKEL--RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL----GSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GK-MALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD-T-ETEGV--PSTAIR-EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF--
--W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMK-R-AVDCP--ENI-KK-EICINKML--NHENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE---PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKE----KKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARIT-------IP-DIKKDRW-Y-
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-A-TS-PKANKEIL-D-EAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV---KITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICT------------------------------IDVYMIMVKCWMIDADSRPK-------FR-ELI----IEF
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-D-AT-EKDLSDLI-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPT-------FK-QLVEDL----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPS-------FR-DLA----LRV
--L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H-S-GP-DQ-QRDFQ-R-EIQILKAL--HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV---KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQR----LPAPPACP------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL-
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP-F-QSIIH--AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML----NWMH---YNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-------AA-QALAHAYF--
-FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKALKKD-V-VLIDD--DVECTMVEKRVLTLA-AENPFLTHLICTFQ--T------KDHLFFVMEFLNGGDLMYHIQ---DKG-------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHI---KIADFGMCKEN----IFGESRAST---FCGTPDYIAPEILQ-----GLK---YTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD----DEDELFESIRV----DTPHYPRWIT----------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF--
-FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKALKKD-V-VLMDD--DVECTMVEKRVLSLA-WEHPFLTHMFCTFQ--T------KENLFFVMEYLNGGDLMYHIQ---SCH-------------------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHI---KIADFGMCKEN----MLGDAKTNT---FCGTPDYIAPEILL-----GQK---YNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ----DEEELFHSIRM----DNPFYPRWLE----------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF--
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N-C-TS-DSVREKFL-Q-EALTMRQF--DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ----VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV---KLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGER----LPMPPNCP------------------------------PTLYSLMTKCWAYDPSRRPR-------FT-ELKAQL----
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E-N-AS-PSELRDLL-S-EFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM---KISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHR----MERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPV-------FA-DISKDL----
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK-S-EEELE--DYM--V-EIDILASC--DHPNIVKLLDAFY--Y------ENNLWILIEFCAGGAVDAVML--ELER-------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI---KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-NPMRVLLKIAKSEP----PTLAQPSRWS----------------------------SNFKDFLKKCLEKNVDARWT-------TS-QLLQHPFV--
ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFLKKR-R-RGQDC--RAEILH-EIAVLELA-KSCPRVINLHEVYE--N------TSEIILILEYAAGGEIFSLCLP-ELAE-------------------------MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRK-----IGHACELRE---IMGTPEYLAPEILN-----YDP---ITTATDMWNIGIIAYMLLT-HTSP---------------FVGE----DNQETYLNISQ----VNVDYSEETFSSVS------------------------QLATDFIQSLLVKNPEKRPT-------AE-ICLSHSWL--
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