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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PRKD1 203
TK ABL1 261
CMGC CDK2 4
CMGC CDK4 6
CAMK DAPK1 13
TK JAK2 849
CMGC MAPK8 26
PD----EVLGSGQFGIVYGGKHR----KTGRDVAIKIIDKLRFPT---KQ--ESQLRN----EVAILQNLH---HPGVVNLECMFE--T------PERVFVVMEKLHGDMLEMILS-SEKG---RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP-QVKLCDFGFARI---IGEKSFRRS---VVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLS-GTFP---------------FNED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL--
--ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-EDTM----EV--EEFL-K----EAAVMKEIK---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR---ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV----KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETE---GV--PSTAIR----EISLLKELN---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPNGGGGGGGL--PISTVR----EVALLRRLEAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDKAPPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV----KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
--YDTGEELGSGQFAVVKKCREK----STGLQYAAKFIKKRRTKS---SR--RGVSREDIEREVSILKEIQ---HPNVITLHEVYE--N------KTDVILILELVAGGELFDFLA--EKE---SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK---IDFGNEFKN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASP---------------FLGD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI--
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-R----EIEILKSLQ---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV----KIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPFQNQ---TH--AKRAYR----ELVLMKCVN---HKNIIGLLNVFT--PQKSLEEFQDVYIVMELMDA-NLCQVIQ----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
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