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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK PTK6 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CSNK2A1 39
TK FGFR1 478
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
Other PLK1 53
AGC PRKACA 44
TK SRC 270
--F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-RDNL-LH-QQMLQ-S------EIQAMKKL--RHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DS--------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC---KVGDFGLARLI------KEDVYLSHDHNIPYKWTAPEALS---RGHYSTKSDVWSFGILLHEMFSRGQVPYP-GM-----------SNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL-----------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-K------EAAVMKEI--KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLA---YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI-----------DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---------
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIR------EISLLKEL--RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF---------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIR------EISLLKEL--NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---------
--W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--ENI-KK------EICINKML--NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y--------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL--NHPCIIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL---------
--W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLELSTKNR--ER-WCH------EIQIMKKL--NHANVVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD----VDQGSLCTS---FVGTLQYLAPELFE---NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPVKKKKIK--R-----------EIKILENL-RGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF----YHPGQEYNV---RVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF---------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-S------EMEMMKMIG-KHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDI-H-H--IDYYKKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV-----------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----------
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKNR--------------ELQIMRKL--DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-A------EANLMKQL--QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM-----------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRPFQNQTH--AKRAYR------ELVLMKCV--NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI---------
LQG---LRPVGSGAYGSVCSAYDA-------RLRQKVAVKKLSRPFQSLIH--ARRTYR------ELRLLKHL--KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL---RILDFGLAR------QADEEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF---------
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AKRTYR------ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF---------
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPFQNQTH--AKRAYR------ELVLMKCV--NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI---------
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRPFQNQTH--AKRAYR------ELVLLKCV--NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----ACTNFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI---------
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSLLLKPH--QREKMS-----MEISIHRSL--AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF---------
--F-ERIKTLGTGSFGRVMLVKHK-------ETGNHYAMKILDKQKVVKLK--QIEHTL-----NEKRILQAV--NFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG-----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI---QVTDFGFAK------RVKGRTWT---LCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD--------------QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF---------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-Q------EAQVMKKL--RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---------
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