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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK RET 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK EGFR 712
TK EPHA3 621
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK KIT 589
TK LCK 245
TKL MAP3K7 36
TK MERTK 587
TK MET 1078
TK MST1R 1082
STE OXSR1 17
AGC PDPK1 82
TK PTK2 422
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S-EFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARNILVAE---GR-KMKISDFGLSRDV---Y---E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI--PPERLFNLL-KTGHRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K-EAAVMKEI-KHPNLVQLLGVCT-REPP-----FYIITEFMTYGNLLDYLR---------EC--------------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGE---NH-LVKVADFGLSRLM-------T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI--DLSQVYELL-EKDYRMERPEGCP--------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-D-FL-M-EALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR---------ETRP---------------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEENH---FIHRDIAARNCLLTCPGPGR-VAKIGDFGMARDI---Y---R--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK--SNQEVLEFV-TSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR-EVEIQSHL-RHPNILRLYGYFH-DATR-----VYLILEYAPLGTVYRELQ--------KLS------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKR---VIHRDIKPENLLLGS---AG-ELKIADFGWSV---------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN-----TYQETY-KRISRVEFTFPDFVT------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-E-IL-D-EAYVMASV-DNPHVCRLLGICL--TST-----VQLITQLMPFGCLLDYVR---------EH---------------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLEDRR---LVHRDLAARNVLVKT---PQ-HVKITDFGLAKLL---G---A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI--PASEISSIL-EKGERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRR-D-FL-G-EASIMGQF-DHPNIIRLEGVVT-KSKP-----VMIVTEYMENGSLDSFLR---------KH---------------------------------------------------------------------------D-AQFTVIQLVGMLRGIASGMKYLSDMG---YVHRDLAARNILINS---NL-VCKVSDFGLSRVL---E---D--DPEA-AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM--SNQDVIKAV-DEGYRLPPPMDCP--------------AALYQLMLDCWQKDRNNRPKFEQIVSIL-------------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S-EMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLR---------ARRPPGMEY------------------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLASQK---CIHRDLAARNVLVTE---NN-VMKIADFGLARDI---N---N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI--PVEELFKLL-KEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A-EANVMKTL-QHDKLVKLHAVVT--KEP-----IYIITEFMAKGSLLDFLK---------SD--------------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQRN---YIHRDLRAANILVSA---SL-VCKIADFGLARVI-------E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM--SNPEVIRAL-ERGYRMPRPENCP--------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-E-FL-N-EASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLR---------SLRPEM------------------------------------------------------------------ENNPVL-APPSLSKMIQMAGEIADGMAYLNANK---FVHRDLAARNCMVAE---DF-TVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL--SNEQVLRFV-MEGGLLDKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-E-FL-N-EASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR---------SLRPEA------------------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNAKK---FVHRDLAARNCMVAH---DF-TVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL--SNEQVLKFV-MDGGYLDQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFDQEIKVMAKC-QHENLVELLGFSS-DGDD-----LCLVYVYMPNGSLLDRLSC-----LDGTP------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENH---HIHRDIKSANILLDE---AF-TAKISDFGLARASE-----KFAQTVMT--SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEH--REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--------
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTERE-A-LM-S-ELKVLSYLGNHMNIVNLLGACT-IGGP-----TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LALDLEDLLSFSYQVAKGMAFLASKN---CIHRDLAARNILLTH---GR-ITKICDFGLARDI---K---N--DSNY--VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMI-KEGFRMLSPEHAP--------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-----------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A-EANLMKQL-QHQRLVRLYAVVT--QEP-----IYIITEYMENGSLVDFLK---------TP--------------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEERN---YIHRDLRAANILVSD---TL-SCKIADFGLARLI-------E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM--TNPEVIQNL-ERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
----IEVEEVVGRGAFGVVCKAKWR---------AKDVAIKQIE-------S-ESERK-A-FI-V-ELRQLSRV-NHPNIVKLYGACL---NP-----VCLVMEYAEGGSLYNVLH---------GA--------------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA---GGTVLKICDFGTACDI-------------Q--THMTNNKGSAAWMAPEVFE-GSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLP--------------KPIESLMTRCWSKDPSQRPSMEEIVKI--M-----------
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLD--N-SS-QREIE-E-FL-S-EAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL---------YSRL----------------------------------------------------------------------ETGP-KHIPLQTLLKFMVDIALGMEYLSNRN---FLHRDLAARNCMLRD---DM-TVCVADFGLSKKI---Y---S--GDYY--RQGRIAKMPVKWIAIESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGV--QNHEMYDYL-LHGHRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L-----------
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T-EGIIMKDF-SHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLRNFIR---------NE---------------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLASKK---FVHRDLAARNCMLDE---KF-TVKVADFGLARDM---Y---D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV--NTFDITVYL-LQGRRLLQPEYCP--------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
-THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-R--I-TE-MQQVE-A-FL-R-EGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR---------SP---------------------------------------------------------------------------Q-RNPTVKDLISFGLQVARSMEYLAEQK---FVHRDLAARNCMLDE---SF-TVKVADFGLARDI---L---D--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHI--DPFDLTHFL-AQGRRLPQPEYCP--------------DSLYQVMQQCWEADPAVRPTFRVLV----GEV---------
----YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLE--K-CQTSM--D-E--LLK-EIQAMSQC-HHPNIVSYYTSFV-VKDE-----LWLVMKLLSGGSVLDIIKHIVAKGEHKSG------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKNG---QIHRDVKAGNILLGE---DG-SVQIADFGVSAFLAT--GGDITRNKVR--KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKY--PPMKVLMLT-LQNDPPSLETGVQDKE--MLK---KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF-----------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR-ERDVMSRL-DHPFFVKLYFTFQ-DDEK-----LYFGLSYAKNGELLKYIR--------KIG------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGKG---IIHRDLKPENILLNE---DM-HIQITDFGTAKVLS-----PESKQARA--NS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG-----NEYLIF-QKIIKLEYDFPEKFF------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q-EALTMRQF-DHPHIVKLIGVIT--ENP-----VWIIMELCTLGELRSFLQ---------VR---------------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLESKR---FVHRDIAARNVLVSS---ND-CVKLGDFGLSRYM-------E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGV--KNNDVIGRI-ENGERLPMPPNCP--------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q-EAQVMKKL-RHEKLVQLYAVVS--EEP-----IYIVTEYMSKGSLLDFLK---------GE--------------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANILVGE---NL-VCKVADFGLARLI-------E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM--VNREVLDQV-ERGYRMPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q-EITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLE---------PG------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEK---KIHRDIKAANVLLSE---HG-EVKLADFGVAGQL-------TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSEL--HPMKVLFLI-PKNNPPTLEGNYS--------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R-EVNAMHSL-DHRNLIRLYGVVL--TPP-----MKMVTELAPLGSLLDRLR---------KH---------------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLESKR---FIHRDLAARNLLLAT---RD-LVKIGDFGLMRAL--PQ---N--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL--NGSQILHKIDKEGERLPRPEDCP--------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R-EAQIMHQL-DNPYIVRLIGVCQ--AEA-----LMLVMEMAGGGPLHKFLV---------GK---------------------------------------------------------------------------R-EEIPVSNVAELLHQVSMGMKYLEEKN---FVHRDLAARNVLLVN---RH-YAKISDFGLSKAL--GA---D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFI-EQGKRMECPPECP--------------PELYALMSDCWIYKWEDRPDFLTVEQR--M-----------
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