|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK1 203
CAMK DAPK2 23
AGC PKN2 657
AGC PRKACA 44
AGC PRKX 49
AGC ROCK2 92
--YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW---EERDIMAFAN---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHL----KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF
--YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL---HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE--IEDGVEFKNIFGTPEFVAPEIVN----YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRK--RLT-----IQEALRHPWI
FR--CCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM---CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV----KIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS----TEAISIMRRLLRRNPER--RLGASEKDAEDVKKHPFF
-F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL---NEKRILQAVN---FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI----QVTDFGFAK----RVKGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF
FD--TLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVH---NEKSVLKEVS---HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHI----KLTDFGFAKK----LVDRTWTLCGTPEYLAPEVIQ----SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLD----FHVKDLIKKLLVVDRTR--RLGNMKNGANDVKHHRWF
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW---EERDIMAFAN---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL----KLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF
|