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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA6 203
CMGC CDC2 4
CAMK DAPK1 13
CAMK DAPK3 13
Other NEK2 8
Other NEK3 4
CAMK PHKG1 20
CAMK PHKG2 24
AGC RPS6KA1 62
AGC RPS6KA2 59
CAMK STK33 116
Other TTK 525
---FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-------ERDILVEV-N-HPFIVKLHYAFQT--EGKLYLILDFLRGGDVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLDEIGHI---------KLTDFGLSKES--VDQEKKAYSFCGTVEYMAPEVVN-----------RRGHSQSADWWSYGVLMFEMLTGTLPFQGK---DRNETMNMILKAKLGMPQFLS--------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---YTKIEKIGEGTYGVV---YKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIR-------EISLLKEL-R-HPNIVSLQDVLMQ--DSRLYLIFEFLSM-DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSR-----RVLHRDLKPQNLLIDDKGTI---------KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF----
---YDTGEELGSGQFAVV---KKCREKSTGL---QYAAKFIKKRRTKSSRRGVSREDI---EREVSILKEI-Q-HPNVITLHEVYEN--KTDVILILELVAGGELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLDRNVPKP-----RIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI----
---YEMGEELGSGQFAIV---RKCRQKGTGK---EYAAKFIKKRRLSSSRRGVSREEI---EREVNILREI-R-HPNIITLHDIFEN--KTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLLDKNVPNP-----RIKLIDFGIAHK---IEAGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS----------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI----
---YEVLYTIGTGSYGRC---QKIRRKSDGK---ILVWKELDYGSMTEAEKQMLVS-------EVNLLREL-K-HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---------KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCALMPPFTAF---SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I---
--Y-MVLRMIGEGSFGRA---LLVQHESSNQ---MFAMKEIRLPKSFSNTQN-SRK-------EAVLLAKM-K-HPNIVAFKESFEA--EGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLTQNGKV---------KLGDFGSARLL--SNPMAFACTYVGTPYYVPPEIWE-----------NLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYS----------------------------YELQFLVKQMFKRNPSHRPS-----ATTLLS----RGIV
---YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSG-HPNIIQLKDTYET--NTFFFLVFDLMKRGELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLDDNMNI---------KLTDFGFSCQ---LEPGERLREVCGTPSYLAPEIIECS-----MNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS----------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF----
YDP---KDVIGRGVSSVV---RRCVHRATGH---EFAVKIMEVTAERLSPEQLEEVREA-TRRETHILRQVAG-HPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLT----EKVALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLDDNMQI---------RLSDFGFSCH---LEPGEKLRELCGTPGYLAPEILKCS-----MDETHPGYGKEVDLWACGVILFTLLAGSPPFWHR---RQILMLRMIMEGQYQFSSPEWDDRS----------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF----
---FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKATLKVRDRVRTKM-------ERDILADV-N-HPFVVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLDEEGHI---------KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS--------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
---FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-------ERDILAEV-N-HPFIVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLDEEGHI---------KITDFGLSKEA--IDHDKRAYSFCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS--------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF----
---YTFGRILGKGSFGIV---IEATDKETET---KWAIKKVNKEKAGSSAVKLLER-------EVNILKSV-K-HEHIIHLEQVFET--PKKMYLVMELCEDGELKEILD----RKGHFSENETRWIIQSLASAIAYLHNN-----DIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKK-QSRSEAMLQATCGTPIYMAPEVIS-----------AHDYSQQCDIWSIGVVMYMLLRGEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS----------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL----
---YSILKQIGSGGSSKV---FQVLNEKKQ----IYAIKYVNLEEADNQTLDSYRN-------EIAYLNKLQQHSDKIIRLYDYEIT--DQYIYMVMECGNI-DLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV-DGML---------KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV----
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