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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC SGK1 203
CAMK CASK 12
CMGC CDK2 4
CAMK CHEK2 220
CAMK DAPK1 13
AGC GRK6 186
CAMK MAPKAPK2 64
AGC RPS6KA1 62
---FHFLKVIGKGSFGKV---LLARHKAEEVFYAVKVLQKKAILKKKEEKHIM-----SERNVLLKNV-KHPFLVGLHFSFQT----ADKLYFVLDYINGGELF-YHLQ---RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHI----VLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH---KQPYDRTVDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNIT--------------------------NSARHLLEGLLQKDRTKRLGAK-DDFMEIKSHV--FF
---YELCEVIGKGPFSVV---RRCINRETGQQFAVKIVDVAKFTSSPGLSTEDL---KREASIC-HML-KHPHIVELLETYSS----DGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSA-PVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLSGCLPFYGT-----KERLFEGIIKGKYKMNPRQWSHIS----------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL--
---FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDTETEGVPSTAIR------EISLL-KEL-NHPNIVKLLDVIHT----ENKLYLVFEFLHQ-DLK-KFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL-KKL-NHPCIIKIKNFF-D----AEDYYIVLELMEGGELF-DKVV---GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--
---YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI--EREVSIL-KEI-QHPNVITLHEVYEN----KTDVILILELVAGGELF-DFLA---EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI--
--F-RQYRVLGKGGFGEV---CACQVRATGKMYACKKLEKKRIKKRKGEAMAL-----NEKQIL-EKV-NSRFVVSLAYAYET----KDALCLVLTLMNGGDLK-FHIYH-MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI----RISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF--
KVT---SQVLGLGINGKV---LQIFNKRTQEKFALKMLQDCPKAR-------R------EVELH-WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF-SRIQD-RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA-ILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM------ERDIL-ADV-NHPFVVKLHYAFQT----EGKLYLILDFLRGGDLF-TRLS---KEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN---RQGHSHSADWWSYGVLMFEMLTGSLPFQGK----DRKETMTLILKAKLGMPQFLS--------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
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