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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK SRC 203
TK ABL1 261
TK ALK 1116
CMGC CDK2 4
CMGC CDK9 2.7.11.23
TK EGFR 712
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK KIT 589
TK LCK 245
CMGC MAPK12 27
STE OXSR1 17
TK PTK2B 425
TK RET 724
AGC RPS6KA1 62
STE STK24 24
TK TNK2 150
TK ZAP70 338
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-P--GTM-SP--E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK---------GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---
----ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-E--DTM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCTR--------EPPFYIITEFMTYGNLLDYLR---------EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP-------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-E--VCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSLQ--------SLPRFILLELMAGGDLKSFLR---------ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP-------------------------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I---
----FQKVEKIGEGTYGVV---YKARNK-------LTGEVVALKKIRLD--TETEGV--P-STAIR-EISLLKEL-NHPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA------SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF-------GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---
----YEKLAKIGQGTFGEV---FKARHR-------KTGQKVALKKVLME--NEKEGF--P-ITALR-EIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS-------NVLV-----------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSL---AKNSQPNRY-TN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGN-TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---
---F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-E--ATS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR---------EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT-------------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF-
---I-SIDKVVGAGEFGEV---CSGRLK----LPSKKEISVAIKTLK-V--GYT-EKQRR-DFL-G-EASIMGQF-DHPNIIRLEGVVTK--------SKPVMIVTEYMENGSLDSFLR---------KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E---D--DPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP-------------------------------AALYQLMLDCWQKDRNNRPK-----FEQIVSIL-----
---L-RKLKVLGSGVFGTV---HKGVWIP---EGESIKIPVCIKVIE-D--KSG-RQSFQ-AVT-D-HMLAIGSL-DHAHIVRLLGLCP---------GSSLQLVTQYLPLGSLLDHVR---------QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P---P--DDKQ-LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT-------------------------------IDVYMVMVKCWMIDENIRPT-----FKELANE--F---
---L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-S--DAT-EKDLS-DLI-S-EMEMMKMIGKHKNIINLLGACTQ--------DGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT-------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACTQ--------DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N---N--IDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT-------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----
----LKLEKKLGAGQFGEV---WMATYN--------KHTKVAVKTMK-P--GSM-SV--E-AFL-A-EANVMKTL-QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK---------SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP-------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L---
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-E--AAS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVSQ--------GQPTLVIMELMTRGDLKSYLR---------SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP-------------------------------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I---
----ITLLRELGQGSFGMV---YEGNARD--IIKGEAETRVAVKTVN-E--SAS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVSK--------GQPTLVVMELMAHGDLKSYLR---------SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP-------------------------------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL-----
-VGG----NKMGEGGFGVV---YKGYVN-------NTT--VAVKKLAAM--VDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSD--------GDDLCLVYVYMPNGSLLDRLSC-----LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ
----LSFGKTLGAGAFGKV---VEATAYG--LIKSDAAMTVAVKMLK-P--SAH-LTERE-ALM-S-ELKVLSYLGNHMNIVNLLGACTI--------GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K---N--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP-------------------------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I---
----LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-Q--GSM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK---------TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---
----YRDLQPVGSGAYGAV---CSAVDG-------RTGAKVAIKKLYRP--FQSELF--A-KRAYR-ELRLLKHM-RHENVIGLLDVFTPDET--LDDFTDFYLVMPFMGT-DLGKLMK---------HE-----------------------------------------------------------------------------KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLAR----------QADSEM-TG---YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGS-DHLDQLKEI-MKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF---
----YELQEVIGSGATAVV---QAAYCA-------PKKEKVAIKRINLE--KCQTSM--D-E-LLK-EIQAMSQC-HHPNIVSYYTSFVV--------KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLAT--GGDITRNKVR-KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKY-PPMKVLMLT-LQNDPPSLETGVQDKE--MLK--------------------KYGKSFRKMISLCLQKDPEKRPT-----AAELLRHKFF---
---V-VLNRILGEGFFGEV---YEGVYT----NHKGEKINVAVKTCK-K--DCT-LDNKE-KFM-S-EAVIMKNL-DHPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE---------RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVL-EKGDRLPKPDLCP-------------------------------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L---
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-E--NAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACSQ--------DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS-------------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-----
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKA--TLKVRD--R-VRTKM-ERDILADV-NHPFVVKLHYAFQT--------EGKLYLILDFLRGGDLFTRLS--------KEV-----------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEA-------IDHEKKA-YS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK----DRKETM-TLILKAKLGMPQFLS-----------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY-
----FTKLEKIGKGSFGEV---FKGIDN-------RTQKVVAIKIIDLE--EAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYLK--------DTKLWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS-------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---
---L-RLLEKLGDGSFGVV---RRGEWD----APSGKTVSVAVKCLK-PDVLSQ-PEAMD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR---------KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ---N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP-------------------------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L---
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-Q--GTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV---------GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP-------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M---
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