|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TEK 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK DDR1 572
TK EPHA1 624
TK EPHA3 621
TK FLT1 827
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TK TIE1 839
--IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY--------------VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
--ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY--------------TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
--ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTY--------------TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
--ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS--------------HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
--LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY--------------RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTLKD-TSPGGQWWNFLREATIMGQF-SHPHILHLEGVVT-KRKPIMIITEFMENGALDAFLRER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT--------------YETQGGKIPIRWTAPEAIAHRI---FTTASDVWSFGIVMWEVLSFGD-KPYGEM-SNQEVMKSI----EDGYR----LPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL--
-I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLKV-GYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEA-------------AYTTRGGKIPIRWTSPEAIAYRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL--
--LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKMLKE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY--------------VRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
--ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY--------------RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY--------------VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
--LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY--------------VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
--LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY--------------TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
-I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTLKD-ASDNA-RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY--------------RVGGHTMLPIRWMPPESIMYRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV----LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
-I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKALKD-PTLAA-RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV----LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
-L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY--------------VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
-L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY--------------ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
--ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKMLKE-YASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVY--------------VKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----MEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
|