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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL TGFBR1 203
TK ABL1 261
TKL BRAF 456
TK CSK 195
TK EPHB4 615
TK FGR 263
TK FYN 271
TK LCK 245
TKL RAF1 349
TK SRC 270
IV--LQESIGKGRFGEVWRGKWR---GEE--VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADN-KDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK---TL
--ITMKHKLGGGQYGEVYEGVWK---KYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCT-R----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F--
--ITVGQRIGSGSFGTVYKGKWH------GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK----S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LPYSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA--SI-
--LKLLQTIGKGEFGDVMLGDYR-----GNKVAVKCIK-N-DAT-AQ---AFLAEASVMTQLRHSNLVQLLGVIVEE----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-------------SSTQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR----------VPYPRI-----PLKDVVPRVEKGYK----MDAPDGCP------PAVYEVMKNCWHLDAAMRPSFLQLREQL---
-V-KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-G-GYT-ERQRREFLSEASIMGQFEHPNIIRLEGVVT-N----SMPVMILTEFMENGALDSFLRLN-DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-ENS--S--DPTYTSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE----------RPYWDM-----SNQDVINAIEQDYR----LPPPPDCP------TSLHQLMLDCWQKDRNARPRFPQVVSAL---
--ITLERRLGTGCFGDVWLGTWN----GSTKVAVKTLK-P-GTM-SP--KAFLEEAQVMKLLRHDKLVQLYAVVS------EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGERLACKIADFGLARLI-------K--DDEYNPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR----------IPYPGM-----NKREVLEQVEQGYH----MPCPPGCP------ASLYEAMEQTWRLDPEERPTFEYLQSFL---
--LQLIKRLGNGQFGEVWMGTWN----GNTKVAIKTLK-P-GTM-SP--ESFLEEAQIMKKLKHDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR----------VPYPGM-----NNREVLEQVERGYR----MPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL---
--LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L--
VM--LSTRIGSGSFGTVYKGKWH------GDVAVKILK-VVDPT-PEQFQAFRNEVAVLRKTRHVNILLFMGYMT------KDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK----S--R--WSGSQQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LPYSHI-N---NRDQIIFMVGRGYASPDLSKLYKNCP------KAMKRLVADCVKKVKEERPLFPQILSS-I--
-L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-P-GTM-SP--EAFLQEAQVMKKLRHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VPYPGM-----VNREVLDQVERGYR----MPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L--
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