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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ZAP70 203
Other AURKA 133
CMGC CDK2 4
CAMK DAPK1 13
TK EGFR 712
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
STE MAP2K1 68
STE MAP2K2 72
TK MST1R 1082
STE OXSR1 17
TK PTK2B 425
TK RET 724
TK SRC 270
STE STK24 24
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KADTEEMM-R----EAQIMHQL-DNPYIVRLIGVCQ--AEALMLVMEMAGGGPLHKFLV---------GK-----------------------REEIPVSNVAELLHQVSMGMKYLEE-KNFVHRDLAARNVLLVNRHYA----KISDFGLSKAL--GA---D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR----EVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGEL----KIADFGWSV---------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT----------------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--PSTAIR----EISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDA------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLINTEGAI----KLADFGLARAF-------GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKRR-TKSSR--RGVSREDIEREVSILKEI-QHPNVITLHEVYE-NKTDVILILELVAGGELFDFLA--------EKE-------------------------SLTEEEATEFLKQILNGVYYLHS-LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK--------IDFGNEF--KN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS------------------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI--
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D----EAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVKTPQHV----KITDFGLAKLL---G---A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT------------------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSDLV-S----EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-QKCIHRDLAARNVLVTENNVM----KIADFGLARDI---N---N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT------------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM-SV--EAFL-A----EANVMKTL-QHDKLVKLHAVVT--KEPIYIITEFMAKGSLLDFLK---------SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVSASLVC----KIADFGLARVI-------E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP------------------------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L--
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERIEFL-N----EASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR---------SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-NKFVHRDLAARNCMVAEDFTV----KIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP------------------------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERIEFL-N----EASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR---------SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-KKFVHRDLAARNCMVAHDFTV----KIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP------------------------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
----FEKISELGAGNGGVVFKVSHK-------PSGL-VMARKLIHLE-IKPAI--RNQIIR----ELQVLHEC-NSPYIVGFYGAFY-SDGEISICMEHMDGGSLDQVLK--------KAG-------------------------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI----KLCDFGVSG---------QLIDSMA--NS---FVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI--
---F-ERISELGAGNGGVVTKVQHR-------PSGLIMARKLIHLEI-KPA-I--RNQIIR----ELQVLHEC-NSPYIVGFYGAFY-SDGEISICMEHMDGGSLDQVLK--------EAK-------------------------RIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI----KLCDFGVSG---------QLIDSMA--NS---FVGTRSYMAPERLQ-GTHYSVQSDIWSMGLSLVELAV-GRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI--
-THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-RI-TE-MQQVEAFL-R----EGLLMRGL-NHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIR---------SP-----------------------QRNPTVKDLISFGLQVARSMEYLAE-QKFVHRDLAARNCMLDESFTV----KVADFGLARDI---L---D--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCP------------------------------------------------DSLYQVMQQCWEADPAVRPTFRVLV----GEV
----YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLEK-CQTSM--DE-LLK----EIQAMSQC-HHPNIVSYYTSFV-VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHK-NGQIHRDVKAGNILLGEDGSV----QIADFGVSAFLAT--GGDITRNKVR--KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE--MLK-------------------------------------KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF--
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-KD-CT-LDNKEKFM-S----EAVIMKNL-DHPHIVKLIGIIE--EEPTWIIMELYPYGELGHYLE---------RN-----------------------KNSLKVLTLVLYSLQICKAMAYLES-INCVHRDIAVRNILVASPECV----KLGDFGLSRYI-------E--DEDY--YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP------------------------------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L--
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-S----EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVAEGRKM----KISDFGLSRDV---Y---E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS------------------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-Q----EAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK---------GE----------------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVC----KVADFGLARLI-------E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLEE-AEDEI--EDIQ-Q----EITVLSQC-DSPYVTKYYGSYL-KDTKLWIIMEYLGGGSALDLLE---------PG-------------------------PLDETQIATILREILKGLDYLHS-EKKIHRDIKAANVLLSEHGEV----KLADFGVAGQL-------TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS------------------------------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI--
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