KIDFamMap

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Kinase profiling results of kinases in KIF 1NVQA_UCN (CHEK1, PDB code: 1NVQ, chain A)
Template Kinase: CHEK1 Template inhibitor: UCN 02	178 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C
AKT1	AGC
AKT2	AGC
AKT3	AGC
CDC42BPA	1
CDC42BPB	1
CDC42BPG	1
DMPK	AGC
ROCK1	AGC
ROCK2	AGC
GRK1	AGC
GRK4	AGC
GRK7	AGC
MAST1	AGC
STK38	AGC
STK38L	AGC
PDPK1	AGC
PRKACA	AGC
PRKACB	AGC
PRKX	AGC
PRKCD	AGC
PRKCQ	AGC
PRKCE	AGC
PRKCH	AGC
PRKCI	AGC
PRKG1	AGC
PRKG2	AGC
PKN1	AGC
PKN2	AGC
RPS6KA4	AGC
RPS6KA4	CAMK
RPS6KA5	AGC
RPS6KA5	CAMK
RPS6KB1	AGC
RPS6KA1	AGC
RPS6KA1	CAMK
RPS6KA2	AGC
RPS6KA2	CAMK
RPS6KA3	AGC
RPS6KA6	AGC
RPS6KA6	CAMK
SGK3	AGC
STK32A	AGC
STK32B	AGC
STK32C	AGC
CAMK1G	CAMK
CAMK2A	CAMK
CAMK2B	CAMK
CAMK2D	CAMK
CAMK2G	CAMK
BRSK1	CAMK
BRSK2	CAMK
CHEK1	CAMK
HUNK	CAMK
STK11	CAMK
MARK1	CAMK
MARK2	CAMK
MARK3	CAMK
MARK4	CAMK
MGC42105	3
NUAK1	CAMK
NUAK2	CAMK
KIAA0999	CAMK
SIK1	CAMK
SIK2	CAMK
SNRK	CAMK
STK33	CAMK
CASK	CAMK
DAPK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
STK17A	CAMK
STK17B	CAMK
MAPKAPK2	3
MAPKAPK5	3
MKNK2	CAMK
PHKG1	CAMK
PHKG2	CAMK
PIM1	CAMK
PIM2	CAMK
PIM3	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
CHEK2	CAMK
TSSK1B	CAMK
CDK2	CMGC
CDK3	CMGC
CDK4	CMGC
CDK5	CMGC
CDK9	CMGC
CDC2L5	CMGC
PCTK1	CMGC
PCTK2	CMGC
PCTK3	CMGC
CDK15	CMGC
PFTK1	CMGC
CDKL1	CMGC
CDKL2	CMGC
CDKL3	CMGC
CDKL5	CMGC
CSNK2A1	CMGC
CSNK2A2	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK1	CMGC
MAPK6	CMGC
MAPK10	CMGC
NLK	CMGC
MAPK12	CMGC
MAPK13	CMGC
MAPK14	CMGC
ICK	CMGC
MAK	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
CAMKK1	Other
CAMKK2	Other
CHUK	Other
IKBKE	Other
TBK1	Other
NEK1	Other
NEK5	Other
NEK2	Other
NEK4	Other
NEK9	Other
SBK1	Other
SGK110	Other
STK35	Other
EIF2AK4	Other
EIF2AK2	Other
PLK1	Other
PLK2	Other
PLK3	Other
TLK2	Other
STK36	Other
ULK3	Other
MAP3K15	STE
MAP3K5	STE
MAP3K6	STE
MAP3K1	STE
YSK4	STE
MAP3K2	STE
MAP3K3	STE
MAP3K4	STE
PAK1	STE
PAK2	STE
PAK3	STE
PAK4	STE
PAK6	STE
SLK	STE
STK10	STE
STK24	STE
STK25	STE
MAP2K5	STE
EPHA8	TK
JAK1	TK
FRK	TK
FYN	TK
SRC	TK
BLK	TK
HCK	TK
LYN	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
IRAK4	TKL
LIMK1	TKL
LIMK2	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C
AKT1	AGC
AKT2	AGC
AKT3	AGC
CDC42BPA	AGC
CDC42BPB	AGC
DMPK	AGC
GRK4	AGC
GRK5	AGC
GRK6	AGC
GRK7	AGC
PDPK1	AGC
PKN1	AGC
PKN2	AGC
PRKACA	AGC
PRKACG	AGC
PRKCA	AGC
PRKCB	AGC
PRKCB	AGC
PRKCD	AGC
PRKCE	AGC
PRKCH	AGC
PRKCI	AGC
PRKCQ	AGC
PRKCZ	AGC
PRKG1	AGC
PRKG2	AGC
PRKX	AGC
ROCK1	AGC
ROCK2	AGC
RPS6KA1	AGC
RPS6KA2	AGC
RPS6KA3	AGC
RPS6KA4	AGC
RPS6KA5	AGC
RPS6KA6	AGC
RPS6KB1	AGC
RPS6KB2	AGC
SGK1	AGC
SGK2	AGC
SGK3	AGC
STK38	AGC
BRSK1	CAMK
BRSK2	CAMK
CAMK1G	CAMK
CAMK2A	CAMK
CAMK2B	CAMK
CAMK2D	CAMK
CAMK2G	CAMK
CHEK1	CAMK
CHEK2	CAMK
DAPK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
MAPKAPK2	CAMK
MAPKAPK5	CAMK
MARK1	CAMK
MARK2	CAMK
MARK3	CAMK
MARK4	CAMK
MKNK2	CAMK
NUAK1	CAMK
NUAK2	CAMK
PASK	CAMK
PHKG1	CAMK
PHKG2	CAMK
PIM1	CAMK
PIM2	CAMK
PIM3	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
SIK2	CAMK
STK11	CAMK
STK17A	CAMK
STK33	CAMK
TSSK1B	CAMK
TSSK2	CAMK
CDC2	CMGC
CDC2	CMGC
CDK2	CMGC
CDK3	CMGC
CDK4	CMGC
CDK5	CMGC
CDK6	CMGC
CDK6	CMGC
CDK9	CMGC
CSNK2A1	CMGC
CSNK2A2	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK1	CMGC
MAPK10	CMGC
MAPK12	CMGC
MAPK13	CMGC
MAPK14	CMGC
NLK	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
CAMKK1	Other
CAMKK2	Other
CHUK	Other
IKBKE	Other
NEK1	Other
NEK2	Other
NEK4	Other
NEK8	Other
PLK1	Other
PLK2	Other
PLK3	Other
TBK1	Other
TLK2	Other
ULK3	Other
MAP3K2	STE
MAP3K3	STE
MAP3K5	STE
PAK1	STE
PAK2	STE
PAK3	STE
PAK4	STE
PAK6	STE
SLK	STE
STK10	STE
STK24	STE
STK25	STE
BLK	TK
EPHA8	TK
FRK	TK
FYN	TK
HCK	TK
JAK1	TK
LYN	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
SRC	TK
IRAK4	TKL
LIMK1	TKL