Kinase profiling results of kinases in KIF 2HY0A_306 (CHEK1, PDB code: 2HY0, chain A)
Template Kinase: CHEK1
Template inhibitor: AMG_706

 22 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
PRKCDAGC 
PRKCQAGC 
PRKCEAGC 
PRKCHAGC 
CHEK1CAMK 
MAPKAPK23 
CDK2CMGC 
CDK4CMGC 
CDK5CMGC 
GSK3BCMGC 
MAPK10CMGC 
MAPK14CMGC 
SRCTK 
LYNTK 
BRAFTKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
AKT1AGC     
AKT2AGC     
AKT3AGC     
PRKCAAGC     
PRKCBAGC     
PRKCBAGC     
PRKCDAGC     
PRKCEAGC     
PRKCHAGC     
PRKCQAGC     
PRKCZAGC     
CHEK1CAMK     
MAPKAPK2CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK4CMGC     
CDK5CMGC     
GSK3BCMGC     
MAPK10CMGC     
MAPK14CMGC     
LYNTK     
SRCTK     
BRAFTKL