Kinase profiling results of kinases in KIF 2JDOA_I5S (AKT2, PDB code: 2JDO, chain A)
Template Kinase: AKT2
Template inhibitor: I5S

 10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
AKT3AGC
ROCK1AGC
ROCK2AGC
PRKACAAGC
PRKXAGC
PRKCDAGC
PRKG1AGC
PKN1AGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
PKN1AGC 
PRKACAAGC 
PRKCDAGC 
PRKG1AGC 
PRKXAGC 
ROCK1AGC 
ROCK2AGC