Kinase profiling results of kinases in KIF 3MVHA_WFE (AKT1, PDB code: 3MVH, chain A)
Template Kinase: AKT1
Template inhibitor: N-{[(3s)-3-Amino-1-(5-Ethyl-7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)pyrrolidin-3-Yl]methyl}-2,4-Difluorobenzamide

5 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
ROCK1AGC 
ROCK2AGC 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
AKT1AGC  
AKT2AGC  
AKT3AGC  
ROCK1AGC  
ROCK2AGC