Kinase profiling results of kinases in KIF 2J4ZA_626 (AURKA, PDB code: 2J4Z, chain A)
Template Kinase: AURKA
Template inhibitor: 2j4z

13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
MAPKAPK23    
CDK2CMGC    
GSK3ACMGC    
GSK3BCMGC    
AURKAOther    
AURKBOther    
PLK1Other    
ABL1TK    
ALKTK    
JAK2TK    
JAK3TK    
LCKTK    
ITKTK    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
MAPKAPK2CAMK    
CDK2CMGC    
GSK3ACMGC    
GSK3BCMGC    
AURKAOther    
AURKBOther    
PLK1Other    
ABL1TK    
ALKTK    
ITKTK    
JAK2TK    
JAK3TK    
LCKTK