Kinase profiling results of kinases in KIF 2NP8A_CC3 (AURKA, PDB code: 2NP8, chain A)
Template Kinase: AURKA
Template inhibitor: Aurora Kinase Inhibitor III

14 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
MAPKAPK23    
CSNK2A1CMGC    
MAPK10CMGC    
MAPK8CMGC    
AURKAOther    
ABL1TK    
EGFRTK    
PTK2TK    
PTK2BTK    
FGFR1TK    
JAK2TK    
LCKTK    
LIMK1TKL    
BRAFTKL    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C C C C
MAPKAPK2CAMK          
CSNK2A1CMGC          
MAPK10CMGC          
MAPK8CMGC          
AURKAOther          
ABL1TK          
EGFRTK          
FGFR1TK          
JAK2TK          
LCKTK          
PTK2TK          
PTK2BTK          
BRAFTKL          
LIMK1TKL