Kinase profiling results of kinases in KIF 2X81A_ZZL (AURKA, PDB code: 2X81, chain A)
Template Kinase: AURKA
Template inhibitor: MLN8054

22 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
STK17ACAMK   
STK17BCAMK   
CDK2CMGC   
MAPK8CMGC   
AURKAOther   
AURKBOther   
AURKCOther   
PLK4Other   
STK10STE   
ABL1TK   
ABL2TK   
TNK1TK   
ALKTK   
EGFRTK   
FGFR1TK   
FGFR2TK   
FGFR3TK   
BLKTK   
LCKTK   
BMXTK   
BTKTK   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
STK17ACAMK   
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
MAPK8CMGC   
AURKAOther   
AURKBOther   
AURKCOther   
STK10STE   
ABL1TK   
ABL2TK   
ALKTK   
BLKTK   
BMXTK   
BTKTK   
EGFRTK   
FGFR1TK   
FGFR2TK   
FGFR3TK   
LCKTK