Kinase profiling results of kinases in KIF 3H10A_97B (AURKA, PDB code: 3H10, chain A)
Template Kinase: AURKA
Template inhibitor: MLN8054

 39 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C
SIK1CAMK     
DAPK2CAMK     
STK17ACAMK     
STK17BCAMK     
MAPKAPK53     
CDK2CMGC     
CDK4CMGC     
CSNK2A1CMGC     
MAPK10CMGC     
MAPK8CMGC     
AURKAOther     
AURKBOther     
AURKCOther     
PLK4Other     
STK10STE     
ABL1TK     
ABL2TK     
TNK1TK     
ALKTK     
CSKTK     
EGFRTK     
EPHA3TK     
EPHB1TK     
PTK2BTK     
FERTK     
FGFR1TK     
FGFR2TK     
FGFR3TK     
JAK2TK     
BLKTK     
LCKTK     
BMXTK     
BTKTK     
TECTK     
TEKTK     
TIE1TK     
LIMK1TKL     
BRAFTKL     

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
DAPK2CAMK       
MAPKAPK5CAMK       
STK17ACAMK       
CDC2CMGC       
CDC2CMGC       
CDK2CMGC       
CDK4CMGC       
CSNK2A1CMGC       
MAPK10CMGC       
MAPK8CMGC       
AURKAOther       
AURKBOther       
AURKCOther       
STK10STE       
ABL1TK       
ABL2TK       
ALKTK       
BLKTK       
BMXTK       
BTKTK       
CSKTK       
EGFRTK       
EPHA3TK       
EPHB1TK       
FERTK       
FGFR1TK       
FGFR2TK       
FGFR3TK       
JAK2TK       
LCKTK       
PTK2BTK       
TECTK       
TEKTK       
BRAFTKL       
LIMK1TKL