Kinase profiling results of kinases in KIF 3P9JA_P9J (AURKA, PDB code: 3P9J, chain A)
Template Kinase: AURKA
Template inhibitor: 4-[(5-Methyl-1h-Pyrazol-3-Yl)amino]-2-Phenylphthalazin-1(2h)-One

 32 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
NUAK1CAMK
DAPK1CAMK
CHEK2CAMK
CDK2CMGC
CDK4CMGC
CSNK2A1CMGC
CSNK2A2CMGC
GSK3ACMGC
GSK3BCMGC
MAPK10CMGC
MAPK8CMGC
MAPK9CMGC
AURKAOther
AURKBOther
PLK1Other
PLK2Other
MAP4K2STE
SLKSTE
ABL1TK
ABL2TK
TNK2TK
FERTK
FGFR1TK
RETTK
SYKTK
BMXTK
BTKTK
ITKTK
TXKTK
NTRK1TK
NTRK2TK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK2CAMK 
DAPK1CAMK 
NUAK1CAMK 
CDK2CMGC 
CDK4CMGC 
CSNK2A1CMGC 
CSNK2A2CMGC 
GSK3ACMGC 
GSK3BCMGC 
MAPK10CMGC 
MAPK8CMGC 
MAPK9CMGC 
AURKAOther 
AURKBOther 
PLK1Other 
PLK2Other 
MAP4K2STE 
SLKSTE 
ABL1TK 
ABL2TK 
BMXTK 
BTKTK 
FERTK 
FGFR1TK 
ITKTK 
NTRK1TK 
NTRK2TK 
NTRK3TK 
RETTK 
SYKTK 
TNK2TK 
TXKTK