Kinase profiling results of kinases in KIF 1UWJA_BAX (BRAF, PDB code: 1UWJ, chain A)
Template Kinase: BRAF
Template inhibitor: Sorafenib

 19 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
ABL1TK 
ABL2TK 
DDR1TK 
EPHA1TK 
EPHA3TK 
MUSKTK 
KITTK 
PDGFRBTK 
LCKTK 
TEKTK 
TIE1TK 
NTRK2TK 
NTRK3TK 
FLT1TK 
FLT4TK 
KDRTK 
LIMK1TKL 
LIMK2TKL 
BRAFTKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
ABL1TK 
ABL2TK 
EPHA1TK 
EPHA3TK 
FLT1TK 
FLT4TK 
KDRTK 
KITTK 
LCKTK 
MUSKTK 
NTRK2TK 
NTRK3TK 
PDGFRBTK 
TEKTK 
BRAFTKL 
LIMK1TKL