Kinase profiling results of kinases in KIF 3OCSA_746 (BTK, PDB code: 3OCS, chain A)
Template Kinase: BTK
Template inhibitor: CGI1746, 2

25 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
AKT1AGC    
PDPK1AGC    
AURKAOther    
AURKBOther    
AURKCOther    
PAK4STE    
EGFRTK    
ERBB2TK    
IGF1RTK    
INSRTK    
JAK1TK    
JAK2TK    
JAK3TK    
TYK2TK    
CSF1RTK    
KITTK    
PDGFRATK    
RETTK    
SRCTK    
LCKTK    
BTKTK    
ITKTK    
NTRK1TK    
FLT4TK    
KDRTK    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
AKT1AGC    
PDPK1AGC    
AURKAOther    
AURKBOther    
AURKCOther    
PAK4STE    
BTKTK    
CSF1RTK    
EGFRTK    
ERBB2TK    
FLT4TK    
IGF1RTK    
INSRTK    
ITKTK    
JAK1TK    
JAK2TK    
JAK3TK    
KDRTK    
KITTK    
LCKTK    
NTRK1TK    
PDGFRATK    
RETTK    
SRCTK    
TYK2TK