Kinase profiling results of kinases in KIF 1CKPA_PVB (CDK2, PDB code: 1CKP, chain A)
Template Kinase: CDK2
Template inhibitor: Purvalanol B

 35 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
DAPK3CAMK
CDK2CMGC
CDK3CMGC
CDK4CMGC
CDK5CMGC
CDK7CMGC
CDK9CMGC
PCTK1CMGC
CLK1CMGC
CLK2CMGC
CLK4CMGC
DYRK1ACMGC
DYRK1BCMGC
MAPK3CMGC
MAPK14CMGC
CAMKK2Other
PLK1Other
PLK3Other
TTKOther
PAK4STE
PAK7STE
SLKSTE
ABL1TK
TNK2TK
JAK3TK
MUSKTK
FGRTK
FYNTK
SRCTK
YES1TK
HCKTK
NTRK2TK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
DAPK3CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK3CMGC     
CDK4CMGC     
CDK5CMGC     
CDK6CMGC     
CDK6CMGC     
CDK7CMGC     
CDK9CMGC     
CLK1CMGC     
CLK2CMGC     
CLK4CMGC     
DYRK1ACMGC     
DYRK1BCMGC     
MAPK14CMGC     
MAPK3CMGC     
CAMKK2Other     
PLK1Other     
PLK3Other     
TTKOther     
PAK4STE     
PAK7STE     
SLKSTE     
ABL1TK     
FGRTK     
FYNTK     
HCKTK     
JAK3TK     
MUSKTK     
NTRK2TK     
NTRK3TK     
SRCTK     
TNK2TK     
YES1TK