Kinase profiling results of kinases in KIF 3EZVA_EZV (CDK2, PDB code: 3EZV, chain A)
Template Kinase: CDK2
Template inhibitor: EZV

 36 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
ROCK1AGC
ROCK2AGC
RPS6KA1AGC
RPS6KA1CAMK
CHEK1CAMK
CDK2CMGC
CDK4CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK1CMGC
MAPK10CMGC
MAPK8CMGC
MAPK14CMGC
AURKAOther
AURKBOther
PLK1Other
ABL1TK
TNK2TK
FGFR1TK
JAK2TK
JAK3TK
METTK
FYNTK
SRCTK
YES1TK
BLKTK
HCKTK
LCKTK
LYNTK
ITKTK
IRAK4TKL
ZAKTKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
AKT1AGC     
AKT2AGC     
PRKCAAGC     
PRKCBAGC     
PRKCBAGC     
ROCK1AGC     
ROCK2AGC     
RPS6KA1AGC     
CHEK1CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK4CMGC     
CSNK2A1CMGC     
GSK3BCMGC     
MAPK1CMGC     
MAPK10CMGC     
MAPK14CMGC     
MAPK8CMGC     
AURKAOther     
AURKBOther     
PLK1Other     
ABL1TK     
BLKTK     
FGFR1TK     
FYNTK     
HCKTK     
ITKTK     
JAK2TK     
JAK3TK     
LCKTK     
LYNTK     
METTK     
SRCTK     
TNK2TK     
YES1TK     
IRAK4TKL     
ZAKTKL