Kinase profiling results of kinases in KIF 3EQFA_KSA (MAP2K1, PDB code: 3EQF, chain A)
Template Kinase: MAP2K1
Template inhibitor: k-252a

 42 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
GRK1AGC 
GRK4AGC 
GRK7AGC 
PRKCEAGC 
PKN1AGC 
STK17ACAMK 
CDK2CMGC 
CDK3CMGC 
CDK4CMGC 
CDK9CMGC 
CDKL1CMGC 
CDKL2CMGC 
GSK3ACMGC 
GSK3BCMGC 
ICKCMGC 
MAKCMGC 
STK24STE 
MAP2K1STE 
MAP2K2STE 
MAP2K4STE 
MAP2K5STE 
ABL1TK 
JAK2TK 
JAK3TK 
RETTK 
ZAP70TK 
ITKTK 
TECTK 
IRAK4TKL 
TESK1TKL 
TNNI3KTKL 
MAP3K12TKL 
MAP3K13TKL 
MAP3K10TKL 
MAP3K11TKL 
MAP3K9TKL 
MAP3K7TKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
GRK4AGC  
GRK6AGC  
GRK7AGC  
PKN1AGC  
PRKCAAGC  
PRKCEAGC  
STK17ACAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK3CMGC  
CDK4CMGC  
CDK6CMGC  
CDK6CMGC  
CDK9CMGC  
GSK3ACMGC  
GSK3BCMGC  
PBKOther  
MAP2K1STE  
MAP2K2STE  
STK24STE  
ABL1TK  
ITKTK  
JAK2TK  
JAK3TK  
RETTK  
TECTK  
ZAP70TK  
IRAK4TKL  
MAP3K10TKL  
MAP3K11TKL  
MAP3K7TKL  
MAP3K9TKL