Kinase profiling results of kinases in KIF 1ZLTA_HYM (CHEK1, PDB code: 1ZLT, chain A)
Template Kinase: CHEK1
Template inhibitor: 10E-Hymenialdisine

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
PRKACAAGC
CHEK1CAMK
DAPK3CAMK
PIM1CAMK
CHEK2CAMK
CDK2CMGC
CDK5CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK1CMGC
MAP3K5STE

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
PRKACAAGC
PRKCAAGC
PRKCBAGC
PRKCBAGC
CHEK1CAMK
CHEK2CAMK
DAPK3CAMK
PIM1CAMK
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK5CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK1CMGC
MAP3K5STE