Kinase profiling results of kinases in KIF 2BRBA_PFQ (CHEK1, PDB code: 2BRB, chain A)
Template Kinase: CHEK1
Template inhibitor: 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL

8 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
CDK2CMGC
CDK5CMGC
MAPK1CMGC
AURKAOther
CHUKOther
SRCTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
CHEK1CAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK5CMGC  
MAPK1CMGC  
AURKAOther  
CHUKOther  
SRCTK