Kinase profiling results of kinases in KIF 2E9VA_85A (CHEK1, PDB code: 2E9V, chain A)
Template Kinase: CHEK1
Template inhibitor: macrocyclic inhibitor 17h

 14 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
AKT1AGC  
AKT2AGC  
AKT3AGC  
RPS6KA4AGC  
RPS6KA4CAMK  
CHEK1CAMK  
MARK2CAMK  
MAPKAPK23  
PIM1CAMK  
CDK2CMGC  
GSK3ACMGC  
MAPK13CMGC  
PLK1Other  
PLK3Other  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
AKT1AGC
AKT2AGC
AKT3AGC
RPS6KA4AGC
SGK1AGC
CHEK1CAMK
MAPKAPK2CAMK
MARK2CAMK
PIM1CAMK
CDK2CMGC
GSK3ACMGC
MAPK13CMGC
PLK1Other
PLK3Other