Kinase profiling results of kinases in KIF 2GHGA_A53 (CHEK1, PDB code: 2GHG, chain A)
Template Kinase: CHEK1
Template inhibitor: oxindole pyridine, 11f

 10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
ROCK1AGC 
RPS6KB1AGC 
CHEK1CAMK 
GSK3BCMGC 
PLK2Other 
PLK3Other 
PAK1STE 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
AKT1AGC
AKT2AGC
AKT3AGC
ROCK1AGC
RPS6KB1AGC
CHEK1CAMK
GSK3BCMGC
PLK2Other
PLK3Other
PAK1STE