Kinase profiling results of kinases in KIF 2HXLA_422 (CHEK1, PDB code: 2HXL, chain A)
Template Kinase: CHEK1
Template inhibitor: DB07075

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
PRKCDAGC
PRKCQAGC
CHEK1CAMK
CDK2CMGC
CDK4CMGC
GSK3BCMGC
AURKAOther
AURKBOther
SLKSTE
SRCTK
BRAFTKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
AKT1AGC 
AKT2AGC 
PRKCDAGC 
PRKCQAGC 
PRKCZAGC 
CHEK1CAMK 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK4CMGC 
GSK3BCMGC 
AURKAOther 
AURKBOther 
SLKSTE 
SRCTK 
BRAFTKL