Kinase profiling results of kinases in KIF 3OT3A_22K (CHEK1, PDB code: 3OT3, chain A)
Template Kinase: CHEK1
Template inhibitor: INCB18424

13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
RPS6KA2AGC
RPS6KA2CAMK
CHEK1CAMK
PIM3CAMK
CDK2CMGC
CDK3CMGC
CDK5CMGC
CDK9CMGC
GSK3BCMGC
EIF2AK2Other
PAK4STE
FYNTK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
RPS6KA2AGC  
CHEK1CAMK  
PIM3CAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK3CMGC  
CDK5CMGC  
CDK9CMGC  
GSK3BCMGC  
PAK4STE  
FYNTK  
NTRK3TK