Kinase profiling results of kinases in KIF 2WTCA_VGM (CHEK2, PDB code: 2WTC, chain A)
Template Kinase: CHEK2
Template inhibitor: VGM

 10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
MAPKAPK23
PIM1CAMK
PRKD1CAMK
CHEK2CAMK
MAPK8CMGC
MAPK14CMGC
NEK2Other
SYKTK
TXKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK1CAMK 
CHEK2CAMK 
MAPKAPK2CAMK 
PIM1CAMK 
PRKD1CAMK 
MAPK14CMGC 
MAPK8CMGC 
NEK2Other 
SYKTK 
TXKTK