Kinase profiling results of kinases in KIF 1Z57A_DBQ (CLK1, PDB code: 1Z57, chain A)
Template Kinase: CLK1
Template inhibitor: Debromohymenialdisine

 9 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
MAPKAPK23
CHEK2CAMK
CDK2CMGC
CDK5CMGC
CSNK2A1CMGC
CLK1CMGC
GSK3BCMGC
MAPK1CMGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK2CAMK 
MAPKAPK2CAMK 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK5CMGC 
CLK1CMGC 
CSNK2A1CMGC 
GSK3BCMGC 
MAPK1CMGC