Kinase profiling results of kinases in KIF 1Y57A_MPZ (SRC, PDB code: 1Y57, chain A)
Template Kinase: SRC
Template inhibitor: MPZ

 42 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C
PRKCDAGC     
PRKCQAGC     
CDK2CMGC     
MAPK14CMGC     
ABL1TK     
ABL2TK     
DDR1TK     
DDR2TK     
EGFRTK     
ERBB2TK     
ERBB4TK     
EPHA3TK     
EPHA8TK     
FGFR1TK     
IGF1RTK     
INSRTK     
JAK2TK     
JAK3TK     
TYK2TK     
CSF1RTK     
KITTK     
PDGFRATK     
PDGFRBTK     
RETTK     
FRKTK     
FGRTK     
FYNTK     
SRCTK     
YES1TK     
BLKTK     
HCKTK     
LCKTK     
LYNTK     
SYKTK     
ITKTK     
NTRK1TK     
IRAK1TKL     
BRAFTKL     
RAF1TKL     
TGFBR1TKL     

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PRKCAAGC     
PRKCDAGC     
PRKCQAGC     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
MAPK14CMGC     
ABL1TK     
ABL2TK     
BLKTK     
CSF1RTK     
DDR2TK     
EGFRTK     
EPHA3TK     
EPHA8TK     
ERBB2TK     
ERBB4TK     
FGFR1TK     
FGRTK     
FRKTK     
FYNTK     
HCKTK     
IGF1RTK     
INSRTK     
ITKTK     
JAK2TK     
JAK3TK     
KITTK     
LCKTK     
LYNTK     
NTRK1TK     
PDGFRATK     
PDGFRBTK     
RETTK     
SRCTK     
SYKTK     
TYK2TK     
YES1TK     
BRAFTKL     
IRAK1TKL     
RAF1TKL     
TGFBR1TKL