Kinase profiling results of kinases in KIF 3AOXA_EMH (ALK, PDB code: 3AOX, chain A)
Template Kinase: ALK
Template inhibitor: BIRB_796

 34 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
SLKSTE 
ABL1TK 
ABL2TK 
ALKTK 
LTKTK 
AXLTK 
MERTKTK 
DDR1TK 
DDR2TK 
EGFRTK 
EPHA2TK 
EPHA8TK 
EPHB1TK 
EPHB2TK 
PTK2TK 
FGFR1TK 
FGFR2TK 
IGF1RTK 
INSRTK 
METTK 
MUSKTK 
CSF1RTK 
RETTK 
SRCTK 
YES1TK 
BLKTK 
ITKTK 
NTRK1TK 
NTRK2TK 
NTRK3TK 
FLT4TK 
KDRTK 
MAP3K7TKL 
BRAFTKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
SLKSTE
ABL1TK
ABL2TK
ALKTK
AXLTK
BLKTK
CSF1RTK
DDR2TK
EGFRTK
EPHA2TK
EPHA8TK
EPHB1TK
EPHB2TK
FGFR1TK
FGFR2TK
FLT4TK
IGF1RTK
INSRTK
ITKTK
KDRTK
LTKTK
MERTKTK
METTK
MUSKTK
NTRK1TK
NTRK2TK
NTRK3TK
PTK2TK
RETTK
SRCTK
YES1TK
BRAFTKL
MAP3K7TKL