Kinase profiling results of kinases in KIF 3Q96A_0NF (BRAF, PDB code: 3Q96, chain A)
Template Kinase: BRAF
Template inhibitor: (2s)-N-[3-(2-Aminopropan-2-Yl)-5-(Trifluoromethyl)phenyl]-7-[(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-4-Yl)oxy]-1,2,3,4-Tetrahydronaphthalene-2-Carboxamide

19 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
ABL1TK   
ABL2TK   
DDR1TK   
EPHA1TK   
EPHA3TK   
MUSKTK   
KITTK   
PDGFRBTK   
LCKTK   
TEKTK   
TIE1TK   
NTRK2TK   
NTRK3TK   
FLT1TK   
FLT4TK   
KDRTK   
LIMK1TKL   
LIMK2TKL   
BRAFTKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
ABL1TK  
ABL2TK  
EPHA1TK  
EPHA3TK  
FLT1TK  
FLT4TK  
KDRTK  
KITTK  
LCKTK  
MUSKTK  
NTRK2TK  
NTRK3TK  
PDGFRBTK  
TEKTK  
BRAFTKL  
LIMK1TKL