Kinase profiling results of kinases in KIF 1M17A_AQ4 (EGFR, PDB code: 1M17, chain A)
Template Kinase: EGFR
Template inhibitor: Erlotinib

 43 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
PDPK1AGC 
AURKAOther 
SLKSTE 
MAP2K5STE 
ABL1TK 
ABL2TK 
TNK1TK 
TNK2TK 
ALKTK 
LTKTK 
CSKTK 
DDR1TK 
EGFRTK 
ERBB2TK 
ERBB3TK 
ERBB4TK 
EPHA3TK 
EPHA5TK 
EPHA6TK 
EPHA8TK 
EPHB1TK 
EPHB4TK 
EPHB6TK 
FGFR1TK 
FGFR2TK 
IGF1RTK 
JAK2TK 
JAK3TK 
KITTK 
PDGFRATK 
PDGFRBTK 
RETTK 
FRKTK 
FGRTK 
SRCTK 
YES1TK 
BLKTK 
HCKTK 
LCKTK 
LYNTK 
SYKTK 
BTKTK 
TXKTK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PDPK1AGC     
AURKAOther     
SLKSTE     
ABL1TK     
ABL2TK     
ALKTK     
BLKTK     
BTKTK     
CSKTK     
EGFRTK     
EPHA3TK     
EPHA5TK     
EPHA6TK     
EPHA8TK     
EPHB1TK     
EPHB4TK     
ERBB2TK     
ERBB4TK     
FGFR1TK     
FGFR2TK     
FGRTK     
FRKTK     
HCKTK     
IGF1RTK     
JAK2TK     
JAK3TK     
KITTK     
LCKTK     
LTKTK     
LYNTK     
PDGFRATK     
PDGFRBTK     
RETTK     
SRCTK     
SYKTK     
TNK2TK     
TXKTK     
YES1TK