Kinase profiling results of kinases in KIF 2ITTA_AEE (EGFR, PDB code: 2ITT, chain A)
Template Kinase: EGFR
Template inhibitor: GNF-Pf-5343

26 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
PDPK1AGC   
AURKAOther   
SLKSTE   
ABL1TK   
TNK2TK   
ALKTK   
EGFRTK   
ERBB2TK   
FGFR1TK   
IGF1RTK   
INSRTK   
JAK2TK   
JAK3TK   
KITTK   
PDGFRATK   
PDGFRBTK   
RETTK   
SRCTK   
HCKTK   
LCKTK   
LYNTK   
SYKTK   
ITKTK   
TXKTK   
NTRK1TK   
BRAFTKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
PDPK1AGC    
AURKAOther    
SLKSTE    
ABL1TK    
ALKTK    
EGFRTK    
ERBB2TK    
FGFR1TK    
HCKTK    
IGF1RTK    
INSRTK    
ITKTK    
JAK2TK    
JAK3TK    
KITTK    
LCKTK    
LYNTK    
NTRK1TK    
PDGFRATK    
PDGFRBTK    
RETTK    
SRCTK    
SYKTK    
TNK2TK    
TXKTK    
BRAFTKL