Kinase profiling results of kinases in KIF 2J5FA_DJK (EGFR, PDB code: 2J5F, chain A)
Template Kinase: EGFR
Template inhibitor: 4-anilinoquinazoline deriv. 17

16 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
STK10STE 
TNK2TK 
EGFRTK 
ERBB4TK 
EPHB3TK 
PTK2TK 
FGFR1TK 
JAK3TK 
FYNTK 
SRCTK 
BLKTK 
LCKTK 
BMXTK 
BTKTK 
TXKTK 
BRAFTKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C C
STK10STE        
BLKTK        
BMXTK        
BTKTK        
EGFRTK        
EPHB3TK        
ERBB4TK        
FGFR1TK        
FYNTK        
JAK3TK        
LCKTK        
PTK2TK        
SRCTK        
TNK2TK        
TXKTK        
BRAFTKL