Kinase profiling results of kinases in KIF 2QOCA_ANP (EPHA3, PDB code: 2QOC, chain A)
Template Kinase: EPHA3
Template inhibitor: Phosphoaminophosphonic Acid-Adenylate Ester

 18 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
AURKAOther
NEK2Other
NEK7Other
ABL1TK
TNK2TK
EGFRTK
ERBB3TK
EPHA2TK
EPHA3TK
PTK2BTK
FGFR2TK
IGF1RTK
INSRTK
KITTK
RETTK
SRCTK
LCKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
AURKAOther
NEK2Other
NEK7Other
ABL1TK
EGFRTK
EPHA2TK
EPHA3TK
FGFR2TK
IGF1RTK
INSRTK
KITTK
LCKTK
PTK2BTK
RETTK
SRCTK
TNK2TK