Kinase profiling results of kinases in KIF 1T46A_STI (KIT, PDB code: 1T46, chain A)
Template Kinase: KIT
Template inhibitor: Imatinib

22 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
ABL1TK       
ABL2TK       
DDR1TK       
EPHA3TK       
EPHA8TK       
FGFR1TK       
INSRTK       
JAK2TK       
CSF1RTK       
KITTK       
PDGFRATK       
PDGFRBTK       
FRKTK       
FGRTK       
FYNTK       
SRCTK       
YES1TK       
LCKTK       
LYNTK       
TEKTK       
KDRTK       
BRAFTKL       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
ABL1TK      
ABL2TK      
CSF1RTK      
EPHA3TK      
EPHA8TK      
FGFR1TK      
FGRTK      
FRKTK      
FYNTK      
INSRTK      
JAK2TK      
KDRTK      
KITTK      
LCKTK      
LYNTK      
PDGFRATK      
PDGFRBTK      
SRCTK      
TEKTK      
YES1TK      
BRAFTKL