KIDFamMap

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Kinase profiling results of kinases in KIF 2X9FA_X9F (EPHB4, PDB code: 2X9F, chain A)
Template Kinase: EPHB4 Template inhibitor: X9F	46 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C
AURKC	Other
NEK5	Other
YSK4	STE
ABL1	TK
ABL2	TK
TNK1	TK
ALK	TK
LTK	TK
DDR1	TK
DDR2	TK
EPHB4	TK
EPHB6	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
JAK2	TK
TYK2	TK
CSF1R	TK
RET	TK
ROS1	TK
FRK	TK
FGR	TK
FYN	TK
SRC	TK
YES1	TK
BLK	TK
HCK	TK
LCK	TK
LYN	TK
PTK6	TK
SRMS	TK
SYK	TK
TXK	TK
TEK	TK
TIE1	TK
FLT4	TK
KDR	TK
IRAK1	TKL
IRAK3	TKL
LIMK1	TKL
LIMK2	TKL
BRAF	TKL
RIPK1	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C
AURKC	Other
ABL1	TK
ABL2	TK
ALK	TK
BLK	TK
CSF1R	TK
DDR2	TK
EPHB4	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
FGR	TK
FLT4	TK
FRK	TK
FYN	TK
HCK	TK
JAK2	TK
KDR	TK
LCK	TK
LTK	TK
LYN	TK
PTK6	TK
RET	TK
ROS1	TK
SRC	TK
SRMS	TK
SYK	TK
TEK	TK
TXK	TK
TYK2	TK
YES1	TK
BRAF	TKL
IRAK1	TKL
LIMK1	TKL