Kinase profiling results of kinases in KIF 2X7OA_ZOP (TGFBR1, PDB code: 2X7O, chain A)
Template Kinase: TGFBR1
Template inhibitor: Imatinib

18 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C
STK24STE     
ABL1TK     
ABL2TK     
EPHB1TK     
EPHB4TK     
FRKTK     
FGRTK     
FYNTK     
SRCTK     
LCKTK     
IRAK4TKL     
MAP3K7TKL     
RAF1TKL     
ACVR1TKL     
ACVR1BTKL     
ACVRL1TKL     
TGFBR1TKL     
BMPR2TKL     

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
STK24STE      
ABL1TK      
ABL2TK      
EPHB1TK      
EPHB4TK      
FGRTK      
FRKTK      
FYNTK      
LCKTK      
SRCTK      
ACVR1TKL      
ACVR1BTKL      
ACVRL1TKL      
IRAK4TKL      
MAP3K7TKL      
RAF1TKL      
TGFBR1TKL