Kinase profiling results of kinases in KIF 1ZYSA_199 (CHEK1, PDB code: 1ZYS, chain A)
Template Kinase: CHEK1
Template inhibitor: 2,4-Diamino-5-ketopyrimidine 21

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
AKT1AGC    
AKT2AGC    
PDPK1AGC    
PRKCDAGC    
PRKCQAGC    
CHEK1CAMK    
STK11CAMK    
SIK1CAMK    
MAPKAPK23    
PIM1CAMK    
CDK2CMGC    
CDK4CMGC    
CDK5CMGC    
CSNK2A1CMGC    
GSK3ACMGC    
GSK3BCMGC    
MAPK14CMGC    
AURKAOther    
AURKBOther    
AURKCOther    
NEK2Other    
SRCTK    
HCKTK    
LYNTK    
NTRK1TK    
BRAFTKL    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
AKT1AGC    
AKT2AGC    
PDPK1AGC    
PRKCAAGC    
PRKCBAGC    
PRKCBAGC    
PRKCDAGC    
PRKCQAGC    
PRKCZAGC    
CHEK1CAMK    
MAPKAPK2CAMK    
PIM1CAMK    
STK11CAMK    
CDC2CMGC    
CDC2CMGC    
CDK2CMGC    
CDK4CMGC    
CDK5CMGC    
CSNK2A1CMGC    
GSK3ACMGC    
GSK3BCMGC    
MAPK14CMGC    
AURKAOther    
AURKBOther    
AURKCOther    
NEK2Other    
HCKTK    
LYNTK    
NTRK1TK    
SRCTK    
BRAFTKL