KIDFamMap

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Kinase profiling results of kinases in KIF 2JEDA_LG8 (PRKCQ, PDB code: 2JED, chain A)
Template Kinase: PRKCQ Template inhibitor: 5-Arylidene-3-benzylhydantoin, 30c	67 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C
GRK1	AGC
GRK4	AGC
GRK7	AGC
MAST1	AGC
PDPK1	AGC
PRKCD	AGC
PRKCQ	AGC
PRKCE	AGC
PRKCH	AGC
PKN1	AGC
PKN2	AGC
CAMK2A	CAMK
CHEK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
STK17A	CAMK
STK17B	CAMK
PHKG1	CAMK
PHKG2	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
CDK2	CMGC
CDKL2	CMGC
CSNK2A2	CMGC
DYRK1B	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK10	CMGC
MAPK8	CMGC
ICK	CMGC
AURKB	Other
AURKC	Other
CAMKK1	Other
CAMKK2	Other
SBK1	Other
SLK	STE
STK24	STE
ABL1	TK
ABL2	TK
TNK2	TK
AXL	TK
TYRO3	TK
FER	TK
FES	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
JAK2	TK
JAK3	TK
RET	TK
FGR	TK
FYN	TK
SRC	TK
YES1	TK
BLK	TK
HCK	TK
ZAP70	TK
ITK	TK
TXK	TK
TEK	TK
TIE1	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C
GRK4	AGC
GRK7	AGC
PDPK1	AGC
PKN1	AGC
PKN2	AGC
PRKCB	AGC
PRKCB	AGC
PRKCD	AGC
PRKCE	AGC
PRKCH	AGC
PRKCQ	AGC
CAMK2A	CAMK
CHEK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
PHKG1	CAMK
PHKG2	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
STK17A	CAMK
CDC2	CMGC
CDC2	CMGC
CDK2	CMGC
CSNK2A2	CMGC
DYRK1B	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK10	CMGC
MAPK8	CMGC
AURKB	Other
AURKC	Other
CAMKK1	Other
CAMKK2	Other
SLK	STE
STK24	STE
ABL1	TK
ABL2	TK
AXL	TK
BLK	TK
FER	TK
FES	TK
FGFR2	TK
FGFR3	TK
FGFR4	TK
FGR	TK
FYN	TK
HCK	TK
ITK	TK
JAK2	TK
JAK3	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
RET	TK
SRC	TK
TEK	TK
TNK2	TK
TXK	TK
TYRO3	TK
YES1	TK
ZAP70	TK