Kinase profiling results of kinases in KIF 2VU3A_LZE (CDK2, PDB code: 2VU3, chain A)
Template Kinase: CDK2
Template inhibitor: AT7519

 35 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
PRKCQAGC   
CASKCAMK   
CDK2CMGC   
CDK3CMGC   
CDK4CMGC   
CDK5CMGC   
CDC2L6CMGC   
CDK9CMGC   
CDC2L5CMGC   
PCTK1CMGC   
PCTK2CMGC   
PCTK3CMGC   
CDK15CMGC   
PFTK1CMGC   
CDK11ACMGC   
CDK11ACMGC   
CDKL2CMGC   
CDKL5CMGC   
CLK1CMGC   
CLK2CMGC   
CLK3CMGC   
CLK4CMGC   
DYRK1ACMGC   
DYRK1BCMGC   
DYRK2CMGC   
GSK3ACMGC   
GSK3BCMGC   
ICKCMGC   
MAKCMGC   
AURKAOther   
CAMKK2Other   
NEK2Other   
SLKSTE   
MAP2K1STE   
EPHB3TK   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
PRKCQAGC  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK3CMGC  
CDK4CMGC  
CDK5CMGC  
CDK9CMGC  
CLK1CMGC  
CLK2CMGC  
CLK3CMGC  
CLK4CMGC  
DYRK1ACMGC  
DYRK1BCMGC  
DYRK2CMGC  
GSK3ACMGC  
GSK3BCMGC  
AURKAOther  
CAMKK2Other  
NEK2Other  
MAP2K1STE  
SLKSTE  
EPHB3TK