Kinase profiling results of kinases in KIF 2XCKA_MH4 (PDPK1, PDB code: 2XCK, chain A)
Template Kinase: PDPK1
Template inhibitor: MH4

46 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C
AKT1AGC        
AKT2AGC        
PDPK1AGC        
PRKCDAGC        
PRKCQAGC        
PRKCHAGC        
CHEK1CAMK        
MELKCAMK        
STK33CAMK        
STK17ACAMK        
MAPKAPK23        
CDK2CMGC        
CDK4CMGC        
CDK5CMGC        
CDC2L6CMGC        
CSNK2A1CMGC        
HIPK4CMGC        
GSK3ACMGC        
GSK3BCMGC        
MAPK1CMGC        
MAPK7CMGC        
MAPK10CMGC        
MAPK8CMGC        
MAPK9CMGC        
MAPK14CMGC        
AURKAOther        
AURKBOther        
AURKCOther        
GAKOther        
PLK1Other        
PLK2Other        
PLK3Other        
PLK4Other        
TTKOther        
ABL1TK        
ABL2TK        
EGFRTK        
JAK2TK        
JAK3TK        
RETTK        
LYNTK        
BTKTK        
LIMK2TKL        
BRAFTKL        

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
AKT1AGC      
AKT2AGC      
PDPK1AGC      
PRKCBAGC      
PRKCBAGC      
PRKCDAGC      
PRKCHAGC      
PRKCQAGC      
CHEK1CAMK      
MAPKAPK2CAMK      
MELKCAMK      
STK17ACAMK      
STK33CAMK      
CDC2CMGC      
CDC2CMGC      
CDK2CMGC      
CDK4CMGC      
CDK5CMGC      
CSNK2A1CMGC      
GSK3ACMGC      
GSK3BCMGC      
HIPK4CMGC      
MAPK1CMGC      
MAPK10CMGC      
MAPK14CMGC      
MAPK8CMGC      
MAPK9CMGC      
AURKAOther      
AURKBOther      
AURKCOther      
PLK1Other      
PLK2Other      
PLK3Other      
TTKOther      
ABL1TK      
ABL2TK      
BTKTK      
EGFRTK      
JAK2TK      
JAK3TK      
LYNTK      
RETTK      
BRAFTKL