Kinase profiling results of kinases in KIF 3MTLA_FEF (PCTK1, PDB code: 3MTL, chain A)
Template Kinase: PCTK1
Template inhibitor: indirubin deriv. 7i

 16 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PKN1AGC
MELKCAMK
STK17ACAMK
CDK2CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
GSK3ACMGC
GSK3BCMGC
IKBKEOther
FERTK
JAK2TK
SRCTK
YES1TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PKN1AGC 
MELKCAMK 
STK17ACAMK 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK5CMGC 
CDK6CMGC 
CDK6CMGC 
CDK9CMGC 
GSK3ACMGC 
GSK3BCMGC 
IKBKEOther 
FERTK 
JAK2TK 
SRCTK 
YES1TK