Kinase profiling results of kinases in KIF 2C0TA_L3G (HCK, PDB code: 2C0T, chain A)
Template Kinase: HCK
Template inhibitor: A-641359

48 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C
CHEK1CAMK        
CDK2CMGC        
CDK5CMGC        
NLKCMGC        
MAPK14CMGC        
PLK1Other        
PLK2Other        
PLK3Other        
STK10STE        
ABL1TK        
ABL2TK        
TNK1TK        
TNK2TK        
LTKTK        
CSKTK        
DDR1TK        
DDR2TK        
EGFRTK        
ERBB2TK        
EPHA8TK        
EPHB1TK        
EPHB2TK        
PTK2TK        
PTK2BTK        
IGF1RTK        
JAK2TK        
JAK3TK        
MUSKTK        
CSF1RTK        
KITTK        
PDGFRATK        
PDGFRBTK        
RETTK        
FRKTK        
FYNTK        
SRCTK        
YES1TK        
BLKTK        
HCKTK        
LCKTK        
LYNTK        
BTKTK        
ITKTK        
NTRK1TK        
NTRK2TK        
NTRK3TK        
BRAFTKL        
RAF1TKL        

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
CHEK1CAMK  
CDK2CMGC  
CDK5CMGC  
MAPK14CMGC  
NLKCMGC  
PLK1Other  
PLK2Other  
PLK3Other  
STK10STE  
ABL1TK  
ABL2TK  
BLKTK  
BTKTK  
CSF1RTK  
CSKTK  
DDR2TK  
EGFRTK  
EPHA8TK  
EPHB1TK  
EPHB2TK  
ERBB2TK  
FRKTK  
FYNTK  
HCKTK  
IGF1RTK  
ITKTK  
JAK2TK  
JAK3TK  
KITTK  
LCKTK  
LTKTK  
LYNTK  
MUSKTK  
NTRK1TK  
NTRK2TK  
NTRK3TK  
PDGFRATK  
PDGFRBTK  
PTK2TK  
PTK2BTK  
RETTK  
SRCTK  
TNK2TK  
YES1TK  
BRAFTKL  
RAF1TKL