Kinase profiling results of kinases in KIF 2HK5A_1BM (HCK, PDB code: 2HK5, chain A)
Template Kinase: HCK
Template inhibitor: 1BM

 24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PRKCDAGC
PRKCQAGC
CHEK1CAMK
CDK2CMGC
CDK5CMGC
ABL1TK
TNK2TK
EGFRTK
EPHB4TK
PTK2TK
FGFR3TK
IGF1RTK
JAK2TK
JAK3TK
KITTK
PDGFRATK
ROS1TK
SRCTK
HCKTK
LCKTK
ZAP70TK
BTKTK
IRAK4TKL
RAF1TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PRKCDAGC 
PRKCQAGC 
CHEK1CAMK 
CDK2CMGC 
CDK5CMGC 
ABL1TK 
BTKTK 
EGFRTK 
EPHB4TK 
FGFR3TK 
HCKTK 
IGF1RTK 
JAK2TK 
JAK3TK 
KITTK 
LCKTK 
PDGFRATK 
PTK2TK 
ROS1TK 
SRCTK 
TNK2TK 
ZAP70TK 
IRAK4TKL 
RAF1TKL